Technetium-99m is a meta-stable compound which is constantly formed from molybdenum-99 within the generator. It is formed on site by elution from a molybdenum-99 generator. Technetium-99m is bound to other compounds for the purposes of myocardial perfusion imaging. The isotope decays by a reasonably complex scheme, but most of the photons have an energy of about 80 keV, which is a low energy. It is then transported as a finished product to the location where it is used, which is feasible because it has a half life of 73 hours. Thallium-201 is generated by a cyclotron. 1, 2 The two most commonly used isotopes for myocardial perfusion imaging are thallium-201 and technetium-99m. Comprehensive reviews of imaging fundamentals and procedures are available.
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